As a dietary supplement, take 4 capsules 30-60 minutes prior to weight training with at least 12-24oz of water or juice. Take Plasmagen Only on the days you may actively work out. Most individuals notice the initial vaso-expansion effects within 15-45 minutes after ingestion. Again these effects tend to become substantially more visible every few minutes thereafter. PlasmaGen induces its maximum vaso-expansion/strength inducing effects within 60-90 minutes after ingestion and will taper down to a baseline 6-12 hours after ingestion. DO NOT EXCEED FIVE (5) SERVINGS PER WEEK AND DO NOT USE MORE THAN ONE SERVING PER DAY.